Breast Cancer

Genetics

• autosomic dominant + polygenic inheritance
• hereditary breast cancer (5-10%)
  • BRCA1
  • BRCA2
    • together mutations in these genes account for 3-8% of all breast cancer cases and 20-25% of hereditary/familial cases
• familial breast cancer
• sporadic breast cancer

Available genetic tests

• BRCA1 and BRCA2 - OMIM: 113705 and 600185 - [EDDNAL] [ORPHANET] [GENDIA] [GeneTests]
• OncoVue® Breast Cancer Risk Test (Intergenetics)
• GeneSearch™ (Veridex)
• H/I ™ (AviaraDX)
• MammaPrint® (Agendia)
• Oncotype DX (GenomicHealth)